Biest 50:50 with Progesterone
Two hormones, one daily cream.
Biest 50:50 with Progesterone
Two hormones, one daily cream. Compounded bioidentical hormone replacement — a blend of estriol and estradiol — with micronized progesterone, in a single daily application. Your clinician determines whether this combination is appropriate for you and at what strength.
About the ingredients
The active ingredients are estradiol, estriol, and micronized progesterone, delivered in a topical cream. Compounded medications are prepared by a licensed U.S. 503A compounding pharmacy and are not FDA-approved; they have not been reviewed by the FDA for safety, effectiveness, or quality. Your exact formulation is determined by your clinician.
How to take
Applied to clean, dry skin once daily, at the site and strength your clinician recommends. Rotate application sites.
Why it may be prescribed
Women with a uterus who take estrogen are typically prescribed progesterone alongside it. This formulation combines both in one daily application rather than two separate prescriptions. Whether it is right for you is a decision for your clinician.
Why HerEstrogen?
Care built around you, not a one-size template: a licensed clinician reviews your history, matches a plan to you, and adjusts it as your body responds — 100% online, no insurance needed.
HerEstrogen vs. every other brand
- No hidden fees. The price you see is the price you pay — no surprise charges bolted on at checkout.
- No separate membership fee. Many telehealth brands charge a monthly “platform” fee on top of your medication. Here, one flat price covers everything.
- No consultation fee. Many telehealth brands charge a separate first-consultation fee — often around $100–$250. Here your clinician evaluation is included with your plan, and if a clinician determines treatment isn’t right for you, you pay nothing.
- Free Shipping Included. Free on every order — never an upsell.
- Lifetime Price Lock. Your rate never rises for as long as your plan stays active — in writing, in our Terms.
- Transparent terms. Cancel anytime, no contracts, no cancellation fees — said before you pay, not in fine print after.
- Real clinician care. Evaluation, check-ins, adjustments, and unlimited messaging with licensed U.S. clinicians — not a checkout bot.
How prescriptions work
A licensed clinician reviews your health history and, if appropriate, issues a prescription — typically within 2 business days. Hormone therapy isn’t right for everyone; if a clinician determines it isn’t appropriate for you, you won’t be charged for medication.
Billing & HSA/FSA
Cash-pay with transparent pricing — no insurance hurdles or surprise bills. Many members use HSA/FSA where eligible. Plans renew automatically unless cancelled at least 72 hours before the renewal date; cancel anytime.
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How it works
No office visits. No insurance hassle. Care that fits your life.
Share your details
A private intake about your health — takes about 2 minutes, no cost to start.
A licensed clinician reviews
A licensed clinician reviews your history to determine whether treatment is right for you.
Receive your treatment
If prescribed, your medication ships free, straight to your door.
Questions? Answered.
What is in Biest 50:50?
Estradiol and estriol, combined with micronized progesterone in a single topical cream. Your exact formulation is determined by your clinician.
Why combine three hormones in one cream?
It replaces two separate prescriptions with one daily application. Whether the combination is right for you is a decision for your clinician.
How do I apply it?
To clean, dry skin once daily, at the site and strength your clinician recommends. Rotate application sites.
Do I need insurance?
No. HerEstrogen is a cash-pay service with transparent pricing, and many treatments are HSA/FSA eligible — no insurance hurdles or surprise bills.
How soon will I hear back?
A clinician who specializes in women's hormones typically reviews your intake within 2 business days. If treatment is appropriate, your prescription ships free.
What if it's not right for me?
If a clinician determines treatment isn't appropriate, you won't be charged for medication. You can adjust or cancel your plan anytime — there's no long-term commitment.
Which states do you serve?
We work with licensed clinicians and pharmacies across all 50 states. Some products and lab tests carry state-level restrictions, which are noted before checkout.
Can I cancel anytime?
Yes. There are no contracts and no cancellation fees — you can adjust or cancel your plan anytime. Plans renew automatically unless cancelled at least 72 hours before the renewal date.